Monoclonal free light chains can be found in heavy chain diseases
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چکیده
منابع مشابه
Heavy/Light-chain analysis of monoclonal gammopathies.
Monoclonal gammopathies (M proteins) are associated with an extraordinarily broad array of clinical conditions that range from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma. Three basic goals of the methods used to investigate M proteins are detection, immunochemical characterization, and quantification. Serum protein electrophoresis (SPE) techniques have undergo...
متن کاملMonoclonal vs polyclonal free light chain assays.
Am J Clin Pathol 2009;131:897-903 901 © American Society for Clinical Pathology relative to Freelite (Figure 1). Both patients had negative results for urine BJPs, further undermining the validity of the ELISA assay results. It is possible that the monoclonal antibodies are cross-reacting with the reported IgG λ and IgA λ monoclonal intact immunoglobulins in these patients, leading to falsely r...
متن کاملFree immunoglobulin light chains in connective tissue diseases.
The basic immunoglobulin subunit consists of two heavy and two light chains held together by covalent disulphide bonds. In most cases of myeloma and Waldenstrom's disease there is an excess synthesis of light over heavy chains, resulting in Bence Jones proteinaemia and proteinuria. Furthermore, in some cases ("light chain disease"), there is absence of detectable heavy chain synthesis, and the ...
متن کاملImmunoglobulin Free Light Chain Dimers in Human Diseases
Immunoglobulin free light chain (FLC) kappa (κ) and lambda (λ) isotypes exist mainly in monomeric and dimeric forms. Under pathological conditions, the level of FLCs as well as the structure of monomeric and dimeric FLCs and their dimerization properties might be significantly altered. The abnormally high fractions of dimeric FLCs were demonstrated in the serum of patients with multiple myeloma...
متن کاملHeavy- and free light-chain myeloma associated with peripheral polyneuropathy.
Peripheral polyneuropathy, a rare complication of multiple myeloma, is generally associated with heavy-chain M-proteins and, in very rare instances, with free light-chain myeloma proteins. Here we describe a case of multiple myeloma and polyneuropathy with both monoclonal IgG and free lambda light chains in the blood. The patient also had free lambda light chains in the cerebrospinal fluid and ...
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ژورنال
عنوان ژورنال: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
سال: 2010
ISSN: 0004-5632,1758-1001
DOI: 10.1258/acb.2010.010146